She married Alvise/Alessandro Pisani, a Venetian noble, in 1508.
In 1508, she succeeded her father, Marco, great-grandson of Francesco I Crispo, as lady of Ios and Therasia.
In 1528 she succeeded her grandmother, Lucrezia Loredano (1446–1528) in Antiparos.
She co-ruled with her husband, Alessandro Pisani of Anaphi and Antiparos, jure uxoris.
The islands were conquered by the Osman Turks in 1537.
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